This study evaluated the in vivo potential antihypertensive effect of hydroalcoholic extract of Syzygium cumini leaves (HESC) in\nnormotensive Wistar rats and in spontaneously hypertensive rats (SHR), as well as its in vitro effect on the vascular reactivity of\nresistance arteries.Thehypotensive effect caused by intravenous infusion of HESC (0.01ââ?¬â??4.0mg/kg) in anesthetizedWistar rats was\ndose-dependent and was partially inhibited by pretreatment with atropine sulfate. SHR received HESC (0.5 g/kg/day), orally, for 8\nweeks and mean arterial pressure, heart rate, and vascular reactivity were evaluated. Daily oral administration of HESC resulted\nin a time-dependent blood pressure reduction in SHR, with a maximum reduction of 62%. In the endothelium-deprived superior\nmesenteric arteries rings the treatment with HESC reduced by 40% the maximum effect (????max) of contraction induced by NE. The\ncontractile response to calcium and NE of endothelium-deprived mesenteric rings isolated from untreated SHR was reduced in\na concentration-dependent manner by HESC (0.1, 0.25, and 0.5mg/mL). This study demonstrated that Syzygium cumini reduces\nthe blood pressure and heart rate of SHR and that this antihypertensive effect is probably due to the inhibition of arterial tone and\nextracellular calcium influx.
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